Mutagenicity of ethyl carbamate to lacZ− transgenic mice
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چکیده
منابع مشابه
Potent mutagenicity of urethan (ethyl carbamate) gas in Drosophila melanogaster.
Exposure of spermatozoa to urethan (ethyl carbamate) gas induced a high frequency of X-linked recessive lethal mutations detected by the Muller-5 technique in Drosophila melanogaster. and a clear dose response was observed. Mutagenic activity of urethan gas on mature spermatozoa following 1.5 (2.4% mutations per chromosome) and 5.5 hr (5.5%) exposure is approximately equal to that induced by 10...
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Structural modifications of the multipotential carcinogen ethyl carbamate (urethan), CH3CH2—O---CO—-NH2, generally result in dramatic losses of carcinogenic activity, which usually have been assayed by lung adenoma induction and by initiation of skin papillomas in mice (reviewed in Refs. 12 and 20). One exception is ethyl N-hydroxycanbamate, CH3CH2— O—CO—-NHOH, a metabolite of ethyl c...
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The title compound, C(17)H(19)NO(4), which is a non-toxic insect growth regulator with the common name fenoxycarb, contains two independent and conformationally different mol-ecules in the asymmetric unit. Although the inter-ring dihedral angles are similar [62.21 (15) and 63.00 (14)°], the side-chain orientations differ. In the crystal, the mol-ecules are linked through N-H⋯O hydrogen-bonding ...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 1998
ISSN: 0267-8357,1464-3804
DOI: 10.1093/mutage/13.2.133